I have leg cramps/muscle contraction during therapy, or muscle soreness after use.

Confirm that the intensity is appropriate – strong but comfortable. You can recalibrate. You may also want to decrease the intensity, as long as it remains strong.
Try the other leg. One leg may be more prone to cramping or soreness than the other leg.
Reposition the device to minimize the amount of electrode on the back of the calf. This usually means positioning the device on the inside or outside rotated towards the front (but not right on top of the tibia bone).
If you mostly have cramping/soreness when lying down, make sure that the device is not positioned such that it is compressed between the bed and your leg. Compressing the device forces the electrodes closer to the muscle, making it more likely to activate it. If this is happening, position the device so that it will not be compressed between the bed and your leg in your preferred sleep position to minimize any discomfort.
There is no risk associated with soreness. If you are getting a lot of pain relief from Quell, you may decide it is worth it to keep wearing it, even if you have some soreness as a consequence.

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